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INHALABLE mRNA for vaccines, GENE therapies and more

16 Agosto 2023 by

… The ability to efficiently deliver mRNA to the lung

… for vaccine development, gene therapy, and more

… showed that such mRNA delivery can be accomplished by encapsulating mRNAs of interest

… Polyplex-delivered mRNAs were efficiently translated into protein in the lungs of mice

… limited evidence of toxicity

… was successfully applied as an intranasal SARS-CoV-2 vaccine

… lung-targeted mRNA therapeutics has been limited by poor transfection efficiency

… and risk of vehicle-induced pathology

… intranasal vaccination with spike protein–encoding mRNA polyplexes induced potent cellular and humoral adaptive immunity