NASAL SALINE irrigation to REDUCE severity in HIGH-RISK COVID outpatients
… 55 and older were enrolled within 24 hours of a + PCR COVID-19 test
… between September 24 and December 21, 2020
… isotonic nasal irrigation twice daily for 14 days
… The primary outcome was hospitalization or death from COVID-19 within 28 days
… compared to the CDC Surveillance Dataset covering the same time
… COVID-19 symptoms resulted in one ED visit and no hospitalizations in 42 irrigating with alkalinization [ sodium bicarbonate ]
… one hospitalization of 37 in the povidone-iodine group, (1.27%)
… no deaths
… Of nearly three million CDC cases, 9.47% were known to be hospitalized
… an additional 1.5% mortality in those without hospitalization data
… The total risk of hospitalization or death (11%) was 8.57 times that of enrolled nasal irrigation participants
… SARS-CoV-2+ participants initiating nasal irrigation were over 8 times less likely to be hospitalized than the national rate
Supplemental Material
